Procedure Time
20-40 minutes
Results
Gradual improvement in texture, elasticity & hydration
Downtime
Minimal
Time To Work
Builds over several weeks
Numbing
Topical numbingv
Lasts
6-12 months*
What Are Polynucleotides?
Highly Purified DNA Molecules
Polynucleotides are refined DNA fragments that support the skin’s natural repair environment, making them ideal for early ageing or stressed skin.
Improve Skin Quality
They help enhance skin texture and tone, contributing to a smoother, more refreshed-looking complexion over time.
Gentle, Regenerative Support
Naturally soothing and suitable for sensitive skin, polynucleotides provide regenerative benefits without heat or harsh exfoliation.
How Do Polynucleotides Work?
Hydration
They help the skin retain moisture at a deeper level, supporting a smoother, more comfortable complexion.
Elasticity
They can support fibroblast activity, helping the skin maintain a firmer, more flexible look over time.
Cellular Repair
They help support natural repair processes, contributing to healthier, more resilient-looking skin.
What Skin Concerns Can Polynucleotides Help With?
Under Eye Hollowness
Can support delicate under-eye skin, helping it look smoother and less tired over time.
Fine Lines & Wrinkles
Can support fibroblast activity, which may soften the look of early lines gradually.
Acne Scarring
Can assist natural repair, supporting a more even skin surface in scar-prone areas.
Redness
Suitable for reactive skin and may help calm visible irritation.
Uneven Texture
Can promote smoother-looking skin by supporting natural renewal.
Dull & Dehydrated
Can support skin function and vitality, helping the complexion look more comfortable and refreshed.
Polynucleotides vs Skin Boosters: What’s The Difference?
Skin Boosters
Focus on moisture and superficial radiance.
Polynucleotides
Support deeper tissue repair, elasticity, firmness, and long-term skin quality.
What To Expect During Your Polynucleotides Consultation?
Your polynucleotides consultation will be conducted by our expert dermatology doctor. Our doctor will assess your condition, determine the most suitable treatment, and answer any questions you may have about your skin. If polynucleotides is the best treatment for your skin condition, the procedure can be performed in the clinic on the same day. Rest assured, all our clinics adhere to safety standards monitored by the General Medical Council and we are insured by Cosmetic Insure.
Three simple steps to start your journey
Contact us
Make a no obligation enquiry on our website. You can attach photos for our doctors to asses so we recommend the best treatment options.
You can also WhatsApp us or call us directly on 0800 009 6109. We are here to help you every step of the way.
Your Consultation
Visit your Dr.Derme clinic and meet your specialist for a consultation. During the visit, we will:
- Complete assessment of your skin
- Explain your best treatment options
- Discuss the treatment or procedure
- Answer all your questions
Your Treatment
Start your Polynucleotide treatment at Birmingham's leading skin clinic. Following the treatment, we provide will all the aftercare advice to get the best results. We are here for you with any follow-up queries:
FREQUENTLY ASKED QUESTIONS
Are Polynucleotides Safe?
Yes — medical-grade polynucleotides have a strong safety profile and are widely used in regenerative medicine. They are typically well-tolerated, suitable for sensitive skin, and appropriate for clients seeking a gentler treatment option.
Are Polynucleotides Safe For Skin Of Colour?
Polynucleotides are generally safe for skin of colour because they do not use heat or harsh resurfacing, which can increase pigmentation risk in darker skin tones. Like any injectable treatment, they can cause short-term inflammation, so treatment technique and aftercare are important — especially for clients prone to PIH. Your Dr.Derme doctor will tailor the approach to your skin type to keep the treatment gentle and suitable.
What’s The Difference Between Polynucleotides And PRP?
PRP uses your own platelets, polynucleotides are lab-purified DNA fragments.
Polynucleotides offer consistent, standardised results and are often preferred for predictable treatment planning.
How Many Sessions Will I Need?
Most follow a course of 2–4 sessions, spaced 2–4 weeks apart. Maintenance sessions every 6–12 months can help extend the benefits.
What Aftercare Should I Follow?
After your polynucleotides treatment, follow these simple aftercare steps to keep your skin comfortable and support the recovery process:
Avoid makeup for 24 hours
Keep skincare simple and hydrating for several days
Avoid intense exercise, saunas and heat for 24–48 hours
Use SPF daily
Temporary swelling or mild bruising may occur
When Will I See Results?
Improvements build gradually over several weeks as the skin responds to the treatment. Hydration often improves first, followed by texture, elasticity and overall vibrancy.
Benefits can last up to 6–12 months, with variation from person to person.